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論文リスト


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<2022>


Goto F, Kiyama Y, Ogawa I, Okuno H, Ichise T, Ichise H, Anai M, Kodama T, Yoshida N, Bito H, Manabe T.
Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area. Mol Psychiatry 2022 Jan 8. doi: 10.1038/s41380-021-01408-3. Epub ahead of print. PMID: 34997193.

Wang C, Horigane SI, Wakamori M, Ueda S, Kawabata T, Fujii H, Kushima I, Kimura H, Ishizuka K, Nakamura Y, Iwayama Y, Ikeda M, Iwata N, Okada T, Aleksic B, Mori D, Yoshida T, Bito H, Yoshikawa T, Takemoto-Kimura S, Ozaki N.
. Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. Transl Psychiatry 2022 Feb 26;12(1):84. doi: 10.1038/s41398-022-01851-y. PMID: 35220405; PMCID: PMC8882172.



<2021>


Ohnishi T, Kiyama Y, Arima-Yoshida F, Kadota M, Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Arai M, Miyashita M, Toriumi K, Nozaki Y, Kurokawa R, Suzuki K, Yoshikawa A, Toyota T, Hosoya T, Okuno H, Bito H, Itokawa M, Kuraku S, Manabe T, Yoshikawa T.
Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia. EMBO Mol Med. 2021 Apr 9;13(4):e12574. doi: 10.15252/emmm.202012574. Epub 2021 Mar 3. PMID: 33656268; PMCID: PMC8033514.

Ueda S, Hosokawa M, Arikawa K, Takahashi K, Fujiwara M, Kakita M, Fukada T, Koyama H, Horigane SI, Itoi K, Kakeyama M, Matsunaga H, Takeyama H, Bito H, Takemoto-Kimura S.
Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles. Front Mol Neurosci. 2021 Sep 3;14:741895. doi: 10.3389/fnmol.2021.741895. PMID: 34539345; PMCID: PMC8446640.

Sulistomo HW, Nemoto T, Kage Y, Fujii H, Uchida T, Takamiya K, Sumimoto H, Kataoka H, Bito H, Takeya R.
Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex. Cereb Cortex. 2021 Mar 5;31(4):2205-2219. doi: 10.1093/cercor/bhaa355.

<2020>

Horiai M, Otsuka A, Hidema S, Hiraoka Y, Hayashi R, Miyazaki S, Furuse T, Mizukami H, Teruyama R, Tamura M, Bito H, Maejima Y, Shimomura K, Nishimori K.
Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models. Scientific Report 2020 Dec 17;10(1):22173. doi: 10.1038/s41598-020-79109-0.

Imoto T, Minoshima M, Yokoyama T, Emery BP, Bull SD, Bito H, Kikuchi K.
A Photodeactivatable Antagonist for Controlling CREB-Dependent Gene Expression. ACS Cent Sci. 2020 Oct 28;6(10):1813-1818. doi: 10.1021/acscentsci.0c00736. Epub 2020 Aug 31.

Kojima K, Kurihara R, Sakamoto M, Takanashi T, Kuramochi H, Zhang XM, Bito H, Tahara T, Sudo Y.
Comparative Studies of the Fluorescence Properties of Microbial Rhodopsins: Spontaneous Emission Versus Photointermediate Fluorescence. J Phys Chem B. 2020 Aug 27;124(34):7361-7367. doi: 10.1021/acs.jpcb.0c06560. Epub 2020 Aug 18.

Horigane SI, Hamada S, Kamijo S, Yamada H, Yamasaki M, Watanabe M, Bito H, Ohtsuka T, Takemoto-Kimura S.
Development of an L-type Ca2+ channel-dependent Ca2+ transient during the radial migration of cortical excitatory neurons. Neurosci Res. 2020 Jun 26:S0168-0102(20)30391-6. doi: 10.1016/j.neures.2020.06.003. Online ahead of print.

Fujita H, Oikawa R, Hayakawa M, Tomoike F, Kimura Y, Okuno H, Hatashita Y, Fiallos Oliveros C, Bito H, Ohshima T, Tsuneda S, Abe H, Inoue T.
Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes. J Biol Chem. 2020 Jun 5;295(23):7923-7940. doi: 10.1074/jbc.RA119.010921. Epub 2020 Apr 27.

<2019>

Imoto T, Kawase A, Minoshima M, Yokoyama T, Bito H, Kikuchi K.
Photolytic Release of a Caged Inhibitor of an Endogenous Transcription Factor Enables Optochemical Control of CREB-Mediated Gene Expression. Organic letters 2019 22(1) 22 - 25. doi: 10.1021/acs.orglett.9b03568

Zhang T, Hernandez O, Chrapkiewicz R, Shai A, Wagner MJ, Zhang Y, Wu CH, Li JZ, Inoue M, Gong Y, Ahanonu B, Zeng H, Bito H, Schnitzer MJ.
Kilohertz two-photon brain imaging in awake mice. Nature Methods 2019 October 16, 1119?1122

Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, Yamanaka A.
Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice. Elife 2019 Jun 4;8. pii: e44927. doi: 10.7554/eLife.44927.

Inoue M, Takeuchi A, Manita S, Horigane SI, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.
Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics. Cell 2019 May 16;177(5):1346-1360.e24. doi: 10.1016/j.cell.2019.04.007. Epub 2019 May 9.

Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Kobayashi K, Miyamichi K, Okuno H, Bito H, Sakurai Y, Yamaguchi M, Mori K, Manabe H.
GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice. Scientific Reports 2019 May 9;9(1):7132. doi: 10.1038/s41598-019-43580-1.

<2018>


Attardo A, Lu J, Kawashima T, Okuno H, Fitzgerald JE, Bito H, Schnitzer MJ.
Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1. Cell reports 2018, October 25(3); 640-650.e2

Sonoda K, Matsui T, Bito H, Ohki K.
Astrocytes in the mouse visual cortex reliably respond to visual stimulation. Biochemical and biophysical research communications 2018, October 505(4); 1216-1222

Nishiguchi KM, Fujita K, Tokashiki N, Komamura H, Takemoto-Kimura S, Okuno H, Bito H, Nakazawa T.
Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy. Molecular therapy 2018, October 26(10); 2397-2406

Benner S, Aoki Y, Watanabe T, Endo N, Abe O, Kuroda M, Kuwabara H, Kawakubo Y, Takao H, Kunimatsu A, Kasai K, Bito H, Kakeyama M, Yamasue H.
Neurochemical evidence for differential effects of acute and repeated oxytocin administration. Molecular psychiatry 2018, September

Kikuchi K, Ihara D, Fukuchi M, Tanabe H, Ishibashi Y, Tsujii J, Tsuda M, Kaneda M, Sakagami H, Okuno H, Bito H, Yamazaki Y, Ishikawa M, Tabuchi A.
Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene. Journal of neurochemistry 2018, September

Kamijo S, Ishii Y, Horigane SI, Suzuki K, Ohkura M, Nakai J, Fujii H, Takemoto-Kimura S, Bito H.
A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration. The Journal of Neuroscience 2018, June 38(24); 5551-5566

El-Boustani S, Ip JPK, Breton-Provencher V, Knott GW, Okuno H, Bito H, Sur M.
Locally coordinated synaptic plasticity of visual cortex neurons in vivo. Science 2018, June 360(6395); 1349-1354

Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H.
Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo. The journal of physiological sciences : JPS 2018, May

Yamazaki H, Sasagawa Y, Yamamoto H, Bito H, Shirao T.
CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools. Journal of neurochemistry 2018, April 146(2); 145-159

<2017>


Okuno H, Minatohara K, Bito H.
Inverse synaptic tagging: An inactive synapse-specific mechanism to capture activity-induced Arc/arg3.1 and to locally regulate spatial distribution of synaptic weights. Seminars in cell & developmental biology 2017, September 77; 43-50

Jenks KR, Kim T, Pastuzyn ED, Okuno H, Taibi AV, Bito H, Bear MF, Shepherd JD.
Arc restores juvenile plasticity in adult mouse visual cortex. PNAS 2017, July 114(34); 9182-9187

Nikolaienko O, Eriksen MS, Patil S, Bito H, Bramham CR.
Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience 2017, July 360; 68-80

Inokuchi K, Imamura F, Takeuchi H, Kim R, Okuno H, Nishizumi H, Bito H, Kikusui T, Sakano H.
Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses. Nature communications 2017, July 8; 15977

Rapanelli M, Frick L, Bito H, Pittenger C.
Histamine modulation of the basal ganglia circuitry in the development of pathological grooming. PNAS 2017, June 114(25); 6599-6604

Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H.
Calmodulin kinases: essential regulators in health and disease. Journal of neurochemistry 2017, June 141(6); 808-818

Rapanelli M, Frick L, Pogorelov V, Ohtsu H, Bito H, Pittenger C.
Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders. Translational psychiatry 2017, January 7(1); e1013

Honjoh S, de Vivo L, Okuno H, Bito H, Tononi G, Cirelli C.
Higher Arc Nucleus-to-Cytoplasm Ratio during Sleep in the Superficial Layers of the Mouse Cortex. Frontiers in neural circuits 2017, 11; 60

Steward O, Matsudaira Yee K, Farris S, Pirbhoy PS, Worley P, Okamura K, Okuno H, Bito H.
Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice. Frontiers in molecular neuroscience 2017, 10; 435

<2016>


Kim CK, Yang SJ, Pichamoorthy N, Young NP, Kauvar I, Jennings JH, Lerner TN, Berndt A, Lee SY, Ramakrishnan C, Davidson TJ, Inoue M, Bito H, Deisseroth K.
Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain. Nature Methods 2016, April 13(4); 325-328

Horigane S, Ageta-Ishihara N, Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H.
Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization. Molecular Brain 2016, January 9(1); 8

Gaffield MA, Amat SB, Bito H, Christie JM.
Chronic imaging of movement-related Purkinje cell calcium activity in awake behaving mice. Journal of neurophysiology 2016, January 115(1); 413-422

<2015>

Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM.
Whole-brain mapping of behaviourally induced neural activation in mice. Brain structuire & function 2015, July 220(4); 2043-2057

Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T.
Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease. Cell reports 2015 May 11; 859-865

Fukuchi M, Tabuchi A, Kuwana Y, Watanabe S, Inoue M, Takasaki I, Izumi H, Tanaka A, Inoue R, Mori H, Komatsu H, Takemori H, Okuno H, Bito H, Tsuda M.
Neuromodulatory effect of Gαs- or Gαq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce. The Journal of Neuroscience 2015 Apr 35; 5606-5624

Fukuchi M, Nakashima F, Tabuchi A, Shimotori M, Tatsumi S, Okuno H, Bito H, Tsuda M.
Class I histone deacetylase-mediated repression of the proximal promoter of the activity-regulated cytoskeleton-associated protein gene regulates its response to brain-derived neurotrophic factor. The Journal of Biological Chemistry 2015 Mar 290; 6825-6836

Inoue M, Takeuchi A, Horigane S, Ohkura M, Gengyo-Ando K, Fujii H, Kamijo S, Takemoto-Kimura S, Kano M, Nakai J, Kitamura K, Bito H.
Rational design of a high-affinity, fast, red calcium indicator R-CaMP2. Nature Methods 2015 Jan 12; 64-70 press release

<2014>

Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, Bito H.
Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory. Neuron 2014 Oct 84; 92-106 press release

Nonaka M, Kim R, Sharry S, Matsushima A, Takemoto-Kimura S, Bito H.
Towards a better understanding of cognitive behaviors regulated by gene expression downstream of activity-dependent transcription factors. Neurobiol Learn Mem doi: 10.1016/j.nlm.2014.08.010 , 2014.

Kawashima T, Okuno H, Bito H.
A new era for functional labeling of neurons: activity-dependent promoters have come of age. Front Neural Circuits 2014 Apr 23; 8-23

Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM.
Whole-brain mapping of behaviourally induced neural activation in mice. Brain structure & function DOI 10.1007/s00429-014-0774-0

Okuno H, Bito H.
Elucidation of the nucleus-to-synapse signaling underlying long-lasting synaptic modification: the regulatory role of Arc Arc3.1 in long-term synaptic plasticity. 生化学 86: 18-27

Nonaka M, Fujii H, Kim R, Kawashima T, Okuno H, Bito H.
Untangling the two-way signaling route from synapses to the nucleus, and from the nucleus back to the synapses. Phil Trans Roy Soc B Biol Sci 369: 20130150

<2013>

Ageta-Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, Higashiyama T, Mazitschek R, Bito H, Kinoshita M.
Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.Nature Communications 4: 2532

川島尚之, 尾藤晴彦.
神経活動に依存的な新規の遺伝子プロモーターE-SAREによるニューロンと軸索投射の機能的な標識.First Author's. 2013 http://first.lifesciencedb.jp/archives/7587

Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H.
Functional labeling of neuronal ensemble and axonal projections in vivo using a synthetic activity-dependent promoter E-SARE. Nature Method 10: 889-895, 2013 [PubMed]

Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M.
The immediate early gene Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron 78: 1024-1035, 2013 [PubMed]

Fujii H, Inoue M, Okuno H, Sano Y, Takemoto-Kimura S, Kitamura K, Kano M, Bito H.
Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. Cell Reports 3: 978-987, 2013 [PubMed]

<2012>

Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, Tohyama C.
Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation. PLoS One 7: e50741, 2012 [PubMed]

Watakabe A, Kato S, Kobayashi K, Takaji M, Nakagami Y, Sadakane O, Ohtsuka M, Hioki H, Kaneko T, Okuno H, Kawashima T, Bito H, Kitamura Y, Yamamori T.
Visualization of cortical projection neurons with retrograde TET-off lentiviral vector. PLoS One 7: e46157, 2012 [PubMed]

奥野浩行, 尾藤晴彦.
ArcはCa2+/カルモジュリン依存性キナーゼIIβとの相互作用により不活性なシナプスに集積しAMPA型グルタミン酸受容体のエンドサイトーシスにはたらく. First Author's. http://first.lifesciencedb.jp/archives/4929

Kim R, Okuno H, Bito H.
Deciphering the molecular rules governing synaptic targeting of the memory related protein Arc. Commun. Integr. Biol. 5: 496-498, 2012[Link]

Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H.
Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIβ. Cell 149, 886-898, 2012.[PubMed]

Wei G, Yin Y, Li W, Bito H, She H, Mao Z.
Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors. J. Biol. Chem. 287, 5797-5805, 2012.[PubMed]

Yoshida K, Ono M, Bito H, Mikami T, Sawada H.
Plasmodium induced by SU6656, an Src family kinase inhibitor, is accompanied by a contractile ring defect. Cell Biochem Funct. 2011 Oct 27. doi: 10.1002/cbf.1814. [Epub ahead of print][PubMed]

<2011>

Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H.
Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nature Med. 17, 1473-1480, 2011.[PubMed]

Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C, Bito H, Morris RG.
Schema-dependent gene activation and memory encoding in neocortex. Science 333, 891-895, 2011. [PubMed]

Komatsu T, Johnsson K, Okuno H, Bito H, Inoue T, Nagano T, Urano Y.
Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method. J. Am. Chem. Soc. 133, 6745-6751, 2011.[PubMed]

<2010>

Okuno H.
Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers. Neurosci Res. 69, 175-186, 2010. [PubMed]

Inoue M, Yagishita-Kyo N, Nonaka M, Kawashima T, Okuno H, Bito H.
Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activity. Commun Integr Biol. 3: 443-446, 2010.[PubMed]

奥野浩行
シナプス活動によって誘導されるArcの発現制御機構. 生化学 82(9), 841-846, 2010.

Takemoto-Kimura, S., Suzuki, K., Kamijo, S., Ageta-Ishihara, N., Fujii, H., Okuno, H., & Bito, H..
Differential roles for CaM kinases in mediating excitation-morphogenesis coupling during formation and maturation of neuronal circuits.　Eur. J. Neurosci. 32, 224-230, 2010.[PubMed]

Bito, H.
The chemical biology of synapses and neuronal circuits. Nature Chem.Biol. 6, 560-563, 2010.[PubMed]

Kim, T.K., Hemberg, M., Gray, J.M., Costa, A.M., Bear, D.M., Wu, J., Harmin, D.A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., Markenscoff-Papadimitriou, E., Kuhl, D., Bito, H., Worley, P.F., Kreiman, G., Greenberg, M.E.
Widespread transcription at neuronal activity-regulated enhancers. Nature, 465, 182-187, 2010.[PubMed]

Redondo, R.L., Okuno, H., Spooner, P.A., Frenguelli, B.G., Bito, H. & Morris, R.G.M.
Synaptic tagging and capture: differential role of distinct calcium-calmodulin kinases in protein synthesis-dependent long-term potentiation. J. Neurosci. 30, 4981-4989, 2010.[PubMed]


<2009>

Ageta-Ishihara, N., Takemoto-Kimura, S., Nonaka, M., Adachi-Morishima, A., Kamijo, S., Suzuki, S., Fujii, H., Mano, M., Blaeser, F., Chatila, T.A., Mizuno, H., Hirano, T., Tagawa, Y., Okuno, H. & Bito, H.
Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J. Neurosci. 29, 13720-13729, 2009.[PubMed]

Kawashima, T., Okuno, H., Nonaka, M., Adachi-Morishima, A., Kyo, N., Okamura, M., Takemoto-Kimura, S., Worley, P., Bito, H.
A synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc. Natl. Acad. Sci. USA 106, 316-321, 2009.[PubMed]

Nonaka M.
A Janus-like role of CREB protein: enhancement of synaptic property in mature neurons and suppression of synaptogenesis and reduced network synchrony in early development. J Neurosci. 29, 6389-6391, 2009.[PubMed]

奥野浩行、川島尚之、野中美応、尾藤晴彦
シナプスから核へのシグナリング：シナプス可塑性を長期化する分子機構. 細胞工学 28, 894-899, 2009.

竹本−木村さやか、上田（石原）奈津実、布施俊光、上條諭志、尾藤晴彦
神経疾患と細胞骨格. 分子細胞治療. 8, 243-248, 2009.

井上昌俊、川島尚之、野中美応、竹本−木村さやか、奥野浩行、尾藤晴彦
シナプス長期可塑性の分子基盤. Cognition and Dementia 8, 177-182, 2009.


<2008>

Bito, H., Takemoto-Kimura, S., Okuno, H.
Activity-dependent gene regulation: How do synapses talk to the nucleus and fine-tune neuronal outputs? Molecular Pain (M. Zhuo ed. Springer). 2008.

奥野浩行、藤井哉、尾藤晴彦
情報素子としてのシナプス-構造・機能ならびに新たな疾患制御標的としての意義-. p220-233, in ナノメディシン 宇理須恒雄 編、 オーム社、東京, 2008.

尾藤晴彦、野中美応、布施俊光、藤井哉、竹本-木村さやか、奥野浩行
シナプス機能とＰＳＤ構築を制御する分子機構. 蛋白質核酸酵素 53, 418-423, 2008.


<2007>

Fuse, T., Ohmae, S., Takemoto-Kimura, S., Bito, H.
DCLK1. AfCS/Nature Molecule Pages, doi:10.1038/mp.a003011.01. 2007.

Takemoto-Kimura, S., Ageta-Ishihara, N., Nonaka, M., Adachi-Morishima, A., Mano, T., Okamura, M., Fujii, H., Fuse, T., Hoshino, M., Suzuki, S., Kojima, M., Mishina, M., Okuno, H., Bito, H.
Regulation of dendritogenesis via a lipid raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Neuron 54, 755-770, 2007.[PubMed]

Kiyonaka, S., Wakamori, M., Miki, T., Uriu, Y., Nonaka, M., Bito, H., Beedle, A.M., Mori, E., Hara, Y., De Waard, M., Kanagawa, M., Itakura, M., Takahashi, M., Campbell, K.P., Mori, Y.
The active zone protein RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nature Neurosci., 10, 691-701, 2007.[PubMed]

尾藤晴彦
神経形態とその可塑性を制御するシグナル伝達機構の探索。生化学。79, 5-15, 2007


<2006>

Chowdhury, S., Shepherd, JD., Okuno, H., Lyford, G., Petralia, RS., Plath, N., Kuhl, D., Huganir, RL. & Worley, PF.
Arc interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52, 445-59. 2006.[PubMed]

Sato, K., Suematsu, A., Nakashima, T., Takemoto-Kimura, S., Aoki, K., Morishita, Y., Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., Kodama, T., Chatila, T.A., Bito, H., Takayanagi, H.
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nature Med. 12, 1410-1416, 2006.[PubMed]

Yamana, N., Arakawa, Y., Nishino, T., Kurokawa, K., Tanji, M., Itoh, RE., Monypenny, J., Ishizaki, T., Bito, H., Nozaki, K., Hashimoto, K., Matsuda, M., Narumiya, S.
Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing APC and c-Src. Mol. Cell Biol., 26, 6844-6858, 2006.[PubMed]

Kuriu, T., Inoue, A., Bito, H., Sobue, K., Okabe, S.
Differential control of postsynaptic density scaffolds via actin-dependent and independent mechanisms. J. Neurosci., 26: 7693-7706, 2006.[PubMed]

Ohmae, S., Takemoto-Kimura, S., Okamura, M., Adachi-Morishima, A., Nonaka, M., Fuse, T., Kida, S., Tanji, M., Furuyashiki, T., Arakawa, Y., Narumiya, S., Okuno, H., Bito H.
Molecular identification and characterization of a family of kinases with homology to CaMKI/CaMKIV. J. Biol. Chem. 281, 20427-20439, 2006.[PubMed]

Uemura, K., Kihara, T., Kuzuya, A., Okawa, K., Nishimoto, T., Bito, H., Ninomiya, H., Sugimoto, H., Kinoshita, A., Shimohama, S.
Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. Biochem Biophys Res Commun. 345, 951-958, 2006.[PubMed]

Nonaka, M., Doi, T., Fujiyoshi, Y., Takemoto-Kimura, S., Bito, H.
Essential contribution of the ligand-binding bB-bC loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding and localization of PSD-95. J. Neurosci. 26, 763-774, 2006.[PubMed]

Okuno, H. and Bito H.
CREB1. AfCS/Nature Molecule Pages, doi:10.1038/ mp.a000690.01, 2006.

尾藤晴彦
CaMKカスケードによる神経機能調節。ブレインサイエンス・レビュー２００７（伊藤正男・川合述史編）クバプロ刊、pp.91-104, 2006.


<2005>

Iki, J., Inoue, A., Bito, H., Okabe, S.
Bidirectional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity. Eur. J. Neurosci. 22, 2985-2994, 2005.[PubMed]

Matsuoka, Y., Furuyashiki, T., Yamada, K., Nagai, T., Bito, H., Tanaka, Y., Kitaoka, S., Ushikubi, F., Nabeshima, T., Narumiya, S.
Prostaglandin E receptor EP1 controls impulsive behavior under stress. Proc. Natl. Acad. Sci. USA 102, 16066-16071, 2005.[PubMed]

Hoshino, M., Nakamura, S., Mori, K., Kawauchi, T., Terao, M., Nishimura, Y.V., Fukuda, A., Fuse, T., Matsuo, N., Sone, M., Watanabe, M., Bito, H., Terashima, T., Wright, C.V.E., Kawaguchi, Y., Nakao, K., and Nabeshima, Y.
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron 47, 201-213, 2005.[PubMed]


<2004>

Nemoto, T.., Kojima, T.., Oshima, A., Bito, H., Kasai, H.
Stabilization of exocytosis by dynamic F-actin coating of zymogen granules in pancreatic acini. J. Biol. Chem. 279, 37544-37550, 2004.[PubMed]

Suga, H., Takeda, S., Haga, T., Okamura, M., Takao, K., and Takemoto, K.
Stimulation of increases in intracellular calcium and prostaglandin E2 generation in Chinese hamster ovary cells expressing receptor-Gα16 fusion proteins. J. Biochem. 135, 605-613, 2004.[PubMed]

Takeda, S., Okada, T., Okamura, M., Haga, T., Isoyama-Tanaka, J., Kuwahara, H., and Minamino, N.
The receptor-Gα fusion protein as a tool for ligand screening: A model study using a nociceptin receptor-Gαi2 fusion protein. J. Biochem. 135, 597-604, 2004.[PubMed]

Zhang, Q., Okamura, M., Guo, Z.-D., Niwa, S., and Haga, T.
Effects of partial agonists and Mg2+ ions on the interactions of M2 muscarinic acetylcholine receptor and G protein Gαi1 subunit in the M2-Gαi1 fusion protein. J. Biochem. 135, 589-596, 2004.[PubMed]

奥野浩行、竹本-木村さやか、大前彰吾、岡村理子、石原奈津実、尾藤晴彦
シナプス活動による遺伝子発現制御。（蛋白質核酸酵素　増刊号）蛋白質核酸酵素 49, 411-418, 2004.


<2003>

Bito H.
Dynamic control of neuronal morphogenesis by rho signaling. J Biochem. 134, 315-319, 2003.[PubMed]

Bito H, Takemoto-Kimura S.
Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival. Cell Calcium 34, 425-430, 2003.[PubMed]

尾藤晴彦、竹本-木村さやか、大前彰吾、古屋敷智之、奥野浩行
Ca2+とCaMキナーゼによるシナプス可塑性制御。（実験医学増刊号no.102「脳神経研究２００４」pp.119-124）実験医学, 21, 2393-2398, 2003.

Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Furuyashiki T, Arakawa Y, Narumiya S, Bito H.
Molecular cloning and characteriation of CLICK-III/CaMKIg, a novel membrane anchored neuronal CaMK. J. Biol. Chem. 278, 18597-18605, 2003.[PubMed]

尾藤晴彦、荒川芳輝
中枢神経細胞における突起形態制御機構。脳神経外科速報 13, 845-850, 2003.

Arakawa Y, Bito H, Furuyashiki T, Tsuji T, Takemoto-Kimura S, Kimura K, Nozaki K, Hashimoto N, Narumiya S.
Control of axon elongation via an SDF-1a / Rho / mDia pathway in cultured cerebellar granule neurons. J.Cell Biol. 161, 381-391, 2003.[PubMed]

Matsuoka Y, Furuyashiki T, Bito H, Ushikubi F, Tanaka Y, Kobayashi T, Muro S, Satoh N, Kayahara T, Higashi M, Mizoguchi A, Shichi H, Fukuda Y, Nakao K, Narumiya S.
Impaired adrenocorticotropic hormone response to bacterial bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. Proc. Nat. Acad. Sci. USA 100, 4132-4137, 2003.[PubMed]


<2002>

尾藤晴彦
CREBの神経系における役割-長期記憶とアポトーシスの制御。医学のあゆみ 203, 538-540, 2002.

荒川芳輝、尾藤晴彦
Rho/ROCKと神経細胞形態。BioClinica 17, 1154-1158, 2002

Tokuyama W, Okuno H, Hashimoto T, Li YX, Miyashita Y.
Selective zif268 mRNA induction in the perirhinal cortex of macaque monkeys during formation of visual pair-association memory. J Neurochem. 81, 60-70, 2002.[PubMed]

Furuyashiki T, Arakawa Y, Takemoto-Kimura S, Bito H, Narumiya S.
Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels. Proc. Natl. Acad. Sci. USA 99, 14458-14463, 2002.[PubMed]

尾藤晴彦、古屋敷智之、竹本-木村さやか、荒川芳輝、成宮周
マウス海馬錐体細胞初代培養法。実験医学 20, 2247-2252，2002．


<2001>

Li YX, Hashimoto T, Tokuyama W, Miyashita Y, Okuno H.
Spatiotemporal dynamics of brain-derived neurotrophic factor mRNA induction in the vestibulo-olivary network during vestibular compensation. J Neurosci. 21, 2738-2748, 2001.[PubMed]

Li YX, Tokuyama W, Okuno H, Miyashita Y, Hashimoto T.
Differential induction of brain-derived neurotrophic factor mRNA in rat inferior olive subregions following unilateral labyrinthectomy. Neuroscience 106, 385-394, 2001.[PubMed]

See V, Boutillier AL, Bito H, Loeffler JP.
Calcium/calmodulin- dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons. FASEB J. 15, 134-144, 2001.[PubMed]

Yamasaki T, Kawaji K, Ono K, Bito H, Hirano T, Osumi N, Kengaku M.
Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum. Development 128, 3133-3144, 2001.[PubMed]

Yamamoto M, Hilgemann DH, Feng S, Bito H, Ishihara H, Shibasaki Y, Yin HL.
Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells. J Cell Biol. 152, 867-876, 2001.[PubMed]


<2000>

Tokuyama W, Okuno H, Hashimoto T, Xin Li Y, Miyashita Y.
BDNF upregulation during declarative memory formation in monkey inferior temporal cortex. Nat Neurosci. 3, 1134-1142, 2000.[PubMed]

Hashimoto T, Okuno H, Tokuyama W, Li YX, Miyashita Y.
Expression of brain-derived neurotrophic factor, neurotrophin-3 and their receptor messenger RNAs in monkey rhinal cortex. Neuroscience 95,: 1003-1010, 2000.[PubMed]

Madaule P, Furuyashiki T, Eda M, Bito H, Ishizaki T, Narumiya S.
Citron, a Rho target that affects contractility during cytokinesis. Microsc. Res. Tech. 49, 123-126, 2000.[PubMed]

Bito H, Furuyashiki T, Ishihara H, Shibasaki Y, Ohashi K, Mizuno K, Maekawa M, Ishizaki T, Narumiya S.
A critical role for a Rho-associated kinase p160ROCK in determining axon outgrowth in mammalian CNS neurons. Neuron 26, 431-441, 2000.[PubMed]

Mermelstein PG, Bito H, Deisseroth K, Tsien RW.
Critical dependence of CREB phosphorylation on L-type calcium channels supports a selective response to EPSPs rather than action potentials. J. Neurosci. 20, 266-273, 2000.[PubMed]

Bito H, Deisseroth K, Tsien RW.
Activity-dependent regulation of communication from synapse to nucleus. in "Challenges for Neuroscience in the 21st Century" (O. Hayaishi ed., Japan Scientific Societies Press, Tokyo), pp. 107-120, 2000.


<1999以前>

尾藤晴彦
記憶の分子生物学。脳の科学 21: 1117-1120, 1999.

Okuno H, Tokuyama W, Li YX, Hashimoto T, Miyashita Y.
Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys. J Comp Neurol. 408, 378-398, 1999.[PubMed]

Shiraishi Y, Mizutani A, Bito H, Fujisawa K, Narumiya S, Mikoshiba K, Furuichi T.
Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated Rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J. Neurosci. 19, 8389-8400, 1999.[PubMed]

尾藤晴彦
脳神経系におけるRhoファミリーGTPase。実験医学 17, 839-843, 1999.

Bito H, Kavalali ET, Zhuo M, Deisseroth K, Tsien RW.
Synaptic modulation of dendritic Ca2+-influx and gene expression. Slow Synaptic Responses and Modulation (K. Kuba, H. Higashida, D.A. Brown, T. Yoshioka eds., Springer Verlag, Tokyo), pp.182-188, 1999.

Furuyashiki T, Fujisawa K, Fujita A, Madaule P, Uchino S, Mishina M, Bito H, Narumiya S.
Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. J. Neurosci.19, 109-118,1999.[PubMed]

尾藤晴彦、後藤由季子
神経系のシグナル伝達。実験医学増刊「シグナル伝達研究の最前線」（西田栄介編）羊土社刊, pp.158-165, 1998.

尾藤晴彦
長期記憶のメカニズム-シナプスと核の間のCREBシグナリング- 生化学 70, 466-471, 1998.

Madaule P, Eda M, Watanabe N, Fujisawa K, Matsuoka T, Bito H, Ishizaki T, Narumiya S.
Role of Citron kinase as a target of the small GTPase Rho in cytokinesis. Nature 394, 491-494, 1998.[PubMed]

Fujisawa K, Madaule P, Ishizaki T, Watanabe G, Bito H, Saito Y, Hall A, Narumiya S.
Different regions of Rho determine Rho-selective binding of different classes of Rho- target molecules. J. Biol. Chem.273, 18943-18949, 1998.[PubMed]

Hirose M, Ishizaki T, Uehata M, Kranenburg O, Moolenaar WH, Matsumura F, Maekawa M, Bito H, Narumiya S.
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J.Cell Biol.141,: 1625-1636, 1998.[PubMed]

Bito H
The role of calcium in activity-dependent neuronal gene regulation. Cell Calcium 23, 143-150, 1998.[PubMed]

Bito H, Deisseroth K, Tsien RW.
Ca2+-dependent regulation in neuronal gene expression. Curr. Opin. Neurobiol.7, 419-429,1997.[PubMed]

Okuno H, Kanou S, Tokuyama W, Li YX, Miyashita Y.
Layer-specific differential regulation of transcription factors Zif268 and Jun-D in visual cortex V1 and V2 of macaque monkeys. Neuroscience 81, 653-666, 1997.[PubMed]

Sato T, Tokuyama W, Miyashita Y, Okuno H.
Temporal and spatial dissociation of expression patterns between Zif268 and c-Fos in rat inferior olive during vestibular compensation. Neuroreport 8, 1891-1895, 1997.[PubMed]

Kavalali ET, Zhuo M, Bito H, Tsien RW.
Dendritic Ca2+-channels characterized by recordings from isolated hippocampal dendritic segments. Neuron 18, 651-663, 1997.[PubMed]

Bito H, Deisseroth K, Tsien RW.
CREB phosphorylation and dephosphorylation: a Ca2+- and stimulus duration-dependent switch for hippocampal gene expression. Cell 87, 1203-1214, 1996.[PubMed]

Deisseroth K, Bito H, Tsien RW.
Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple hippocampal synaptic plasticity. Neuron 16, 89-101,1996.[PubMed]

Okuno H, Saffen DW, Miyashita Y.
Subdivision-specific expression of ZIF268 in the hippocampal formation of the macaque monkey. Neuroscience 66, 829-845, 1995.[PubMed]

Bito H, Honda Z, Nakamura M, Shimizu T.
Cloning, expression and tissue distribution of rat platelet-activating factor receptor cDNA. Eur. J. Biochem.221, 211-218, 1994.[PubMed] /font>

Bito H, Mori M, Sakanaka C, Takano T, Honda Z, Gotoh Y, Nishida E, Shimizu T.
Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. J. Biol. Chem. 269, 12722-12730, 1994.[PubMed]

Okuno H, Akahori A, Sato H, Xanthoudakis S, Curran T, Iba H.
Escape from redox regulation enhances the transforming activity of Fos. Oncogene 8, 695-701, 1993.[PubMed]

Bito H, Nakamura M, Honda Z, Izumi T, Iwatsubo T, Seyama Y, Ogura A, Kudo Y, Shimizu T.
Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes Ca2+ in hippocampal neurons. Neuron 9, 285-294, 1992.[PubMed]

尾藤晴彦, 清水孝雄
アラキドン酸とその代謝産物によるＫ＋チャネル活性の調節。実験医学（増刊 「イオンチャネルとレセプター」)御子柴克彦、三品昌美、井村裕夫編, pp.98-106, 1992.

Okuno H, Suzuki T, Yoshida T, Hashimoto Y, Curran T, Iba H.
Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene. Oncogene 6, 1491-1497, 1991.[PubMed]

清水孝雄, 尾藤晴彦
エイコサノイド。蛋白質核酸酵素（増刊「神経生化学」下巻：黒川正則、佐武明、宮本英七編）, pp. 546-560, 1990.

尾藤晴彦, 清水孝雄
アラキドン酸のリポキシゲナーゼ系代謝産物とイオンチャンネル。現代医療, 21, 760 , 1989.

Bito H, Ohishi N, Miki I, Minami M, Tanabe T, Shimizu T, Seyama Y.
Leukotriene A4 hydrolase from guinea pig lung: the presence of two catalytically active forms. J. Biochem.105, 261-264, 1989.[PubMed]

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